FSGS occurs slightly more frequently in men and more frequently in African Americans.1,2 Podocyte loss disrupts the filtration barrier of the kidney and allows plasma proteins, including cytokines, to enter the tubules. This leads to tubule-interstitial injury and the production of proinflammatory cytokines/chemokines, which in turn promote damage to tubule epithelial cells and fibrosis.3,4 The resulting scarring disrupts the kidney’s ability to filter blood and can lead to nephrotic syndrome and ESRD.